Larotrectinib Demonstrates CNS Efficacy in TRK Fusion-Positive Solid Tumors
نویسندگان
چکیده
منابع مشابه
A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.
Larotrectinib, a selective TRK tyrosine kinase inhibitor (TKI), has demonstrated histology-agnostic efficacy in patients with TRK fusion-positive cancers. Although responses to TRK inhibition can be dramatic and durable, duration of response may eventually be limited by acquired resistance. LOXO-195 is a selective TRK TKI designed to overcome acquired resistance mediated by recurrent kinase dom...
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ژورنال
عنوان ژورنال: JCO Precision Oncology
سال: 2019
ISSN: 2473-4284
DOI: 10.1200/po.19.00009